Burden of rheumatic diseases among people with diabetes: A systematic review and meta-analysis

Authors

  • Mahabaleshwar Mamadapur Department of Clinical Immunology and Rheumatology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, Mysuru, India. https://orcid.org/0000-0001-7421-2418
  • Abhay M. Gaidhane Jawaharlal Nehru Medical College and Global Health Academy, School of Epidemiology and Public Health, Datta Meghe Institute of Higher Education and Research, Wardha, India
  • Bijaya K. Padhi Department of Community Medicine and School of Public Health, Postgraduate Institute of Medical Education and Research, Chandigarh, India
  • Quazi S. Zahiruddin Global Health Academy, Division of Evidence Synthesis, School of Epidemiology and Public Health and Research, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, India
  • Rakesh K. Sharma Graphic Era (Deemed to be University), Clement Town, Dehradun, India; Graphic Era Hill University, Clement Town, Dehradun, India
  • Sarvesh Rustagi School of Applied and Life Sciences, Uttaranchal University, Dehradun, India https://orcid.org/0000-0002-1247-1040
  • Prakasini Satapathy Center for Global Health Research, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Medical Laboratories Techniques Department, AL-Mustaqbal University, Babil, Iraq https://orcid.org/0000-0001-7614-8587
  • Sathvik B. Sridhar RAK College of Pharmacy, RAK Medical & Health Sciences University, Ras Al Khaimah, United Arab Emirates https://orcid.org/0000-0002-9100-2508
  • Javedh Shareef Department of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al-Khaimah, United Arab Emirates
  • Sirajunisa Talath Department of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Sciences University, Ras Al-Khaimah, United Arab Emirates https://orcid.org/0000-0002-2334-2332
  • Rajesh K. Yadav Kathmandu Medical College, Kathmandu, Nepal https://orcid.org/0009-0003-7542-1483
  • Rachana Mehta Medical Laboratories Techniques Department, AL-Mustaqbal University, Babil, Iraq; Dr Lalpath Labs Nepal, Chandol, Nepal; Department of Microbiology, Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, Pune, India

DOI:

https://doi.org/10.52225/narra.v4i3.863

Keywords:

Osteoarthritis, rheumatoid arthritis, diabetes, gout, comorbidity

Abstract

Diabetes mellitus type 2 (DM2) is a prevalent metabolic condition affecting over 500 million people globally and associated with serious comorbidities, including various rheumatologic conditions. Some studies have reported a significant association between rheumatological conditions and DM2. However, the global burden of rheumatological conditions among people with DM2 remains unknown. The aim of this study was to assess the cumulative prevalence of rheumatological conditions in DM2 patients. An extensive electronic search was conducted utilizing multiple databases of studies published until January 2024. The quality of the studies included in the review was evaluated using a modified version of the Newcastle-Ottawa Scale (NOS). The overall quality of the studies included was rated as moderate. The review included a total of 13 studies, with 830,649 DM2 patients reported to have rheumatological conditions. Eleven studies were used to determine the individual results of rheumatoid arthritis (RA), gout, and osteoarthritis (OA). The pooled prevalence of OA was 26% (95%CI: 19–32%) and the prediction interval ranged from 6% to 51%. The pooled prevalence of gout disease was 1% (95%CI: 0.0–5.0%), and the prediction interval ranged from 0% to 99%. For RA, the combined prevalence was 0.3% (95%CI: 0.2–0.5%) and the prediction interval ranged from 0% to 5%. In conclusion, this review suggests a considerable prevalence of OA among DM2 patients, while the prevalence of RA and gout was minimal. Early diagnosis and management of certain rheumatologic conditions in individuals with DM2 may help improve health outcomes and prevent premature mortality. Further research is warranted to explore and understand the mechanisms underlying the association between DM2 and rheumatological conditions.

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