Global prevalence and contributing factors of transplant renal artery stenosis in renal transplant recipients: A systematic review and meta-analysis

Fredo  Tamara; Jonny K. Fajar; Camoya  Gersom; Ramadi S. Wicaksono; Alvira  R. Tupamahu; Fariz N. Huda; Fitria R. Sari; Jamaludin A. Dela; Irawati E. Putri; Muhammad A. Sutrisno; Riyantono  Putra; Michael  Dwinata; Yudha  Friatna; Thoha M. Albaar; Agung  Susanto; Ratih TK. Dewi; Aryo  Suseno; Nur  Samsu

doi:10.52225/narra.v4i3.1782

Authors

Fredo Tamara Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Negeri Sebelas Maret, Surakarta, Indonesia
Jonny K. Fajar Department of Internal Medicine, Rumah Sakit Universitas Brawijaya, Malang, Indonesia https://orcid.org/0000-0002-0309-5813
Camoya Gersom Department of Internal Medicine, Ciputra Hospital, Surabaya, Indonesia https://orcid.org/0000-0002-8482-9080
Ramadi S. Wicaksono Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia https://orcid.org/0000-0002-4963-5627
Alvira R. Tupamahu Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia
Fariz N. Huda Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia https://orcid.org/0009-0008-9129-3262
Fitria R. Sari Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia
Jamaludin A. Dela Faculty of Health Sciences, Universitas Brawijaya, Malang, Indonesia https://orcid.org/0009-0008-5465-9026
Irawati E. Putri Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia https://orcid.org/0009-0005-2566-772X
Muhammad A. Sutrisno Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia https://orcid.org/0009-0001-3982-6032
Riyantono Putra Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia https://orcid.org/0009-0000-5017-1084
Michael Dwinata Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia
Yudha Friatna Faculty of Medicine, Universitas Indonesia, Depok, Indonesia
Thoha M. Albaar Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
Agung Susanto Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Negeri Sebelas Maret, Surakarta, Indonesia https://orcid.org/0009-0004-8216-1373
Ratih TK. Dewi Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Negeri Sebelas Maret, Surakarta, Indonesia https://orcid.org/0000-0003-2408-8783
Aryo Suseno Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Negeri Sebelas Maret, Surakarta, Indonesia
Nur Samsu Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia https://orcid.org/0000-0003-4610-3796

DOI:

https://doi.org/10.52225/narra.v4i3.1782

Keywords:

Renal transplant, transplant renal artery stenosis, prevalence, risk factor, meta-analysis

Abstract

Transplant renal artery stenosis (TRAS) is a serious complication of renal transplantation, with its prevalence and associated factors remaining inconclusive. The aim of this study was to assess the global prevalence and risk factors associated with TRAS incidence in renal transplant recipients. We conducted a meta-analysis by collecting data on the prevalence and factors associated with TRAS from articles in Scopus, Embase, and PubMed. The prevalence of TRAS was determined using a single-arm meta-analysis. The factors associated with TRAS were determined using Mantel-Haenszel analysis or inverse variance analysis. Out of 28,599 articles from the searches, 31 of them were included in the analysis. The global prevalence of TRAS was 6% among renal transplant recipients. Diabetes mellitus, hypertension, longer duration of dialysis before transplant, deceased donor, acute rejection, delayed graft function, longer cold ischemic time, and prolonged peak systolic velocity were associated with an increased risk of TRAS. Age, gender, peripheral artery disease (PAD) comorbidity, causes of end-stage renal disease (ESRD), previous dialysis modality, and cytomegalovirus infection were not associated with TRAS incidence. In conclusion, the global prevalence of TRAS in renal transplant recipients is relatively high, and some of the contributing factors to the development of TRAS are preventable. These findings could serve as a guideline for informing the management of TRAS in the future.