Global acceptance and hesitancy of COVID-19 vaccination: A narrative review


  • Wardah Hassan Dow University of Health Sciences, Karachi, Pakistan
  • Syeda K. Kazmi Dow University of Health Sciences, Karachi, Pakistan
  • Muhammad J. Tahir Lahore General Hospital, Lahore, Pakistan; Ameer-ud-Din Medical College, Affiliated with University of Health and Sciences, Lahore, Pakistan
  • Irfan Ullah Kabir Medical College, Gandhara University, Peshawar, Pakistan; Naseer Teaching Hospital, Peshawar, Pakistan
  • Hibban Ar Royan Center for Indonesian Medical Students' Activities (CIMSA), Banda Aceh, Indonesia
  • Marhami Fahriani Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia
  • Firzan Nainu Faculty of Pharmacy, Hasanuddin University, Makassar, Sulawesi Selatan, Indonesia
  • Sandro GV. Rosa Diretoria de Patentes, Divisão de Farmácia - Instituto Nacional da Propriedade Industrial, Rio de Janeiro, Brasil; Programa de Pós-Graduação em Ciências Aplicadas a Produtos para Saúde, Faculdade de Farmácia, Universidade Federal Fluminense, Brasil



COVID-19, COVID-19 vaccine, vaccination, vaccine acceptance, vaccine hesitancy


The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a major global health threat to human civilization and has disrupted many aspects of the community around the globe. Vaccination is one of the prominent measures to control the COVID-19 pandemic. More than 120 vaccines have entered human clinical trials and at least 8 vaccines have been fully approved. However, the success of the COVID-19 vaccination programs depends on how the community accepts the vaccines. Despite COVID-19 vaccination having been initiated for a while now, more than 50% of the global population have not been vaccinated. In some low- and middle-income countries (LMICs), the vaccine coverage is less than 20%. Since the decision to accept the new vaccine is complex, understanding the factors underpinning vaccine acceptance is critical. This review aimed to summarize the COVID-19 vaccine acceptance rate around the globe as well as its associated determinants. Information from this study might be important to formulate effective strategies to increase the COVID-19 vaccine coverage, and to be able to achieve herd immunity.


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Review Article