Acceptance of COVID-19 vaccination at different hypothetical efficacy and safety levels in ten countries in Asia, Africa, and South America

Authors

  • Dott F. Rosiello Department of Public Health and Infectious Disease, Sapienza-University of Rome, Rome, Italy https://orcid.org/0000-0002-6532-1185
  • Samsul Anwar Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia https://orcid.org/0000-0003-3165-2151
  • Amanda Yufika Department of Family Medicine, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia https://orcid.org/0000-0001-8408-9396
  • Rashed Y. Adam Omdurman Teaching Hospital, Khartoum, Sudan https://orcid.org/0000-0002-7841-4807
  • Mohajer IH. Ismaeil Faculty of Medicine, Alzaiem Alazhari University, Khartoum, Sudan https://orcid.org/0000-0003-4864-3454
  • Asma Y. Ismail Department of Internal Medicine, Faculty of Medicine, Sudan International University, Khartoum, Sudan
  • Nesrine BH. Dahman Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
  • Montacer Hafsi Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
  • Manel Ferjani Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia
  • Farah S. Sami Faculty of Medicine, Ain Shams University, Nasr City, Cairo, Egypt
  • Fatma A Monib Faculty of Medicine, Assiut University, Assiut, Egypt
  • Subramaniam R Department of Public Health Dentistry, Indira Gandhi Institute of Dental Sciences, Nellikuzhi, Kothamangalam, Kerala, India https://orcid.org/0000-0003-2863-6708
  • Sunil Anandu Division of Veterinary Parasitology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh, India
  • Md Ariful Haque Department of Orthopedic Surgery, Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan, China https://orcid.org/0000-0003-4632-5153
  • Lirane ED. Ferreto Department of Public Health and Postgraduate Program in Applied Health Sciences, Faculty of Medicine, Western Paraná State University, Brazil https://orcid.org/0000-0002-0757-3659
  • José TO. Aburto Faculty of Medicine, University of La Frontera, Temuco, Chile https://orcid.org/0000-0001-8705-4041
  • Jorge ET. Rojas Faculty of Medicine, University of La Frontera, Temuco, Chile https://orcid.org/0000-0001-7399-3654
  • Seyi S. Enitan Department of Medical Laboratory Science, Babcock University, Ilishan-Remo, Ogun State, Nigeria
  • Akele R. Yomi Department of Medical Laboratory Science, Afe Babalola University, Ado Ekiti, Nigeria
  • Eyiuche D. Ezigbo Department of Medical Laboratory Sciences, Faculty of Health Sciences & Technology University of Nigeria, Enugu State Nigeria https://orcid.org/0000-0001-9397-3706
  • Elham Babadi Research Fellow, Mayo Clinic, Rochester, USA
  • Edris Kakemam Iranian Center of Excellence in Health Management, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran https://orcid.org/0000-0001-7721-6924
  • Najma I. Malik Department of Psychology, University of Sargodha, Sargodha, Pakistan https://orcid.org/0000-0002-3521-1014
  • Irfan Ullah Department of Internal Medicine, Kabir Medical College, Gandhara University, Peshawar, Pakistan https://orcid.org/0000-0003-1100-101X
  • Malik Sallam Department of Pathology, Microbiology and Forensic Medicine, School of Medicine, The University of Jordan, Amman Jordan; Department of Clinical Laboratories and Forensic Medicine, Jordan University Hospital, Amman Jordan; Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, Sweden

DOI:

https://doi.org/10.52225/narra.v1i3.55

Keywords:

COVID-19, COVID-19 vaccine, acceptance, hesitancy, WHO SAGE

Abstract

Vaccine hesitancy, defined as the reluctance or rejection in receiving a vaccine despite its availability, represents a major challenge to global health efforts aiming to control the ongoing COVID-19 pandemic. Understanding the possible factors correlated with COVID-19 vaccine hesitancy using a refined well-informed approach can be helpful to address the phenomenon. The current study aimed to evaluate COVID-19 vaccine acceptance rates using four hypothetical scenarios of varying levels of vaccine efficacy and safety profiles in ten Asian, African and South American countries. These scenarios included: 95% efficacy and 20% side effects (Vaccine A), 75% efficacy and 5% side effects (Vaccine B); 75% efficacy and 20% side effects (Vaccine C) and 50% efficacy and 5% side effects (Vaccine D). This study used a self-administered online survey that was distributed during February–May 2021. The total number of study respondents was 1337 with countries of residence as follows: India (21.1%), Pakistan (12.9%), Sudan (11.2%), Nigeria (9.3%), Iran (8.2%), Bangladesh and Brazil (7.9%), Chile (7.7%), Tunisia (7.6%), and Egypt (6.2%). The overall acceptance rates for COVID-19 vaccination were variable based on varying degrees of safety and efficacy as follows: 55.6% for Vaccine C, 58.3% for Vaccine D, 74.0% for Vaccine A and 80.1% for Vaccine B. The highest levels of COVID-19 vaccine acceptance were observed in Brazil followed by Chile across the four different safety and efficacy scenarios. The lowest COVID-19 vaccine acceptance rates were reported in Egypt and Tunisia for the low safety scenarios (20% side effects), and the low efficacy scenario (50% efficacy). The study revealed the potential effect of vaccine safety and efficacy on the intention to get COVID-19 vaccination. At the same efficacy level, higher possibility of side effects caused a large drop in COVID-19 vaccine acceptance rate. This indicates the importance of accurate communication regarding vaccine safety and efficacy on attitude towards the vaccine and intentions to get vaccinated. Regional differences in COVID-19 vaccine acceptance were observed with the Middle East/North African countries showing the lowest rates and the South American countries displaying the highest vaccine acceptance rates.

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Published

2021-12-01 — Updated on 2022-01-26

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