Celiac disease: Pathogenesis, disease management and new insights into the herbal-based treatments

Pooja Mittal; Disha Arora; Smriti Parashar; Rajat Goyal; Amir Khan; Hitesh Chopra; Dinesh K. Mishra; Rupesh K. Gautam; Kuldeep Dhama

doi:10.52225/narra.v3i2.147

Authors

Pooja Mittal Chitkara College of Pharmacy, Chitkara University, Rajpura, India https://orcid.org/0000-0001-7961-6964
Disha Arora Chandigarh College of Pharmacy, CGC Landran, Mohali, India
Smriti Parashar Vedic Institute of Pharmaceutical Education and Research, Sagar, India https://orcid.org/0000-0002-5283-3907
Rajat Goyal MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, India https://orcid.org/0000-0001-5702-0932
Amir Khan Chitkara College of Pharmacy, Chitkara University, Rajpura, India https://orcid.org/0009-0008-2813-1690
Hitesh Chopra Chitkara College of Pharmacy, Chitkara University, Rajpura, India https://orcid.org/0000-0001-8867-7603
Dinesh K. Mishra Indore Institute of Pharmacy, IIST Campus, Indore, India https://orcid.org/0000-0002-4624-3978
Rupesh K. Gautam Indore Institute of Pharmacy, IIST Campus, Indore, India https://orcid.org/0000-0001-5580-5410
Kuldeep Dhama Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, India https://orcid.org/0000-0001-7469-4752

DOI:

https://doi.org/10.52225/narra.v3i2.147

Keywords:

Celiac disease, autoimmune disorder, gluten, human leukocyte antigen, genetic

Abstract

Celiac disease (CD) is a gluten intolerance autoimmune disorder which its symptoms involve the gastrointestinal tract and sometimes the other organs. It is one of the most prevalent health problems rising in many populations as statistics show that in every 100 people about one person is suffering from CD. It has been observed that the persons who genetically contain the human leukocyte antigen (HLA) DQ2 and HLA DQ8 genes involved in the immune system haplotypes are more prone to develop an allergy to gluten. The only treatment currently available for CD is a strict gluten-free diet. However, recent research has shown promising new insights into the herbal-based treatments of CD. New insight on CD is now offering various prospects to manage its treatment, diagnosis, and serving in the development of advanced therapies. Several herbs and botanical extracts have demonstrated anti-inflammatory, immunomodulatory, and gut-healing properties that make them potential candidates for the management of CD. Here, we provide an updated review on pathogeneses and managements of CD. In particular, we summarize the current understandings of herbal-based treatments for CD and highlights their potential benefits.